You betta check yo'self before you wreck yo'self, Aight
Some interesting articles on dopamine, Prolactin and Norepinephrine.
Refractory period - Wikipedia, the free encyclopedia(sex)
Quote: Another chemical which is considered to be responsible for this effect is prolactin, which represses dopamine, which is responsible for sexual arousal.
The Analyst - Internet Health Report: Condition: Hyperprolactinemia Hyperprolactinaemia - Wikipedia, the free encyclopedia Quote: In men, the most common symptoms of hyperprolactinemia are decreased libido, erectile dysfunction, and infertility. Because men have no reliable indicator such as menstruation to signal a problem, many men with hyperprolactinemia being caused by an adenoma may delay going to the doctor until they have headaches or eye problems caused by the enlarged pituitary pressing against nearby optic nerves. They may not recognize a gradual loss of sexual function or libido. Only after treatment do some men realize they had a problem with sexual function. In men excess prolactin may also cause Gynecomastia.
Dopamine - Wikipedia, the free encyclopedia Quote: Dopamine
Biosynthesis
Dopamine is biosynthesized in the body (mainly by nervous tissue and the medulla of the adrenal glands) first by the hydroxylation of the amino acid L-tyrosine to L-DOPA via the enzyme tyrosine 3-monooxygenase, also known as tyrosine hydroxylase, and then by the decarboxylation of L-DOPA by aromatic L-amino acid decarboxylase (which is often referred to as dopa decarboxylase). In some neurons, dopamine is further processed into norepinephrine by dopamine beta-hydroxylase.
In neurons, dopamine is packaged after synthesis into vesicles, which are then released into the synapse in response to a presynaptic action potential.
Functions in the brain
Dopamine has many functions in the brain, including important roles in behavior and cognition, voluntary movement, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, the substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus....
Cognition and frontal cortex
In the frontal lobes, dopamine controls the flow of information from other areas of the brain. Dopamine disorders in this region of the brain can cause a decline in neurocognitive functions, especially memory, attention, and problem-solving. Reduced dopamine concentrations in the prefrontal cortex are thought to contribute to attention deficit disorder....
Regulating prolactin secretion
Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. [12] Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin. Prolactin also seems to inhibit dopamine release, such as after orgasm, and is chiefly responsible for the refractory period.
Behavior disorders
Deficient dopamine neurotransmission is implicated in attention-deficit hyperactivity disorder, and stimulant medications used to successfully treat the disorder increase dopamine neurotransmission, leading to decreased symptoms
Human sexual response cycle - Wikipedia, the free encyclopedia Prolactin - Wikipedia, the free encyclopedia Quote: Prolactin provides the body with sexual gratification after sexual acts: The hormone counteracts the effect of dopamine, which is responsible for sexual arousal. This is thought to cause the sexual refractory period.[3] The amount of prolactin can be an indicator for the amount of sexual satisfaction and relaxation. Unusually high amounts are suspected to be responsible for impotence and loss of libido (see hyperprolactinemia symptoms). Prolactin also stimulates proliferation of oligodendrocyte precursor cells. These cells differentiate into oligodendrocytes, the cells responsible for the formation of myelin coatings on axons in the central nervous system.[4]
Quote: Diagnostic use
Prolactin levels may be checked as part of a sex hormone workup, as elevated prolactin secretion can suppress the secretion of FSH and GnRH, leading to hypogonadism, and sometimes causing erectile dysfunction in men.
Quote: Low Testosterone Level
Prolactinoma is a condition in which a noncancerous tumor (adenoma) of the pituitary gland in your brain overproduces the hormone prolactin. The major effect of increased prolactin is a decrease in normal levels of sex hormones — estrogen in women and testosterone in men.
Hypogonadism - Wikipedia, the free encyclopedia Quote: Dr. Weinberger then talks about addiction. He says all forms of addiction, from drug abuse to cigarette smoking to gambling, seem to target the dopamine system, adding that not everyone is affected in the same way -- some people seem to have a genetic predisposition toward addiction. He says the problem with drugs like amphetamine or cocaine is they cause a massive increase in dopamine in the brain. A great, very positive experience may cause a 30-40 % increase in the amount of dopamine between cells. When you take a drug like amphetamine or cocaine, you get a several thousand-fold increase in dopamine between cells. He says, "It's a huge sledgehammer of a message like, 'Wow! This is something I want to experience again!'" So it becomes very difficult to resist that experience.
Plus, if you are a chronic user, when you are off the drug, you don't just go back to a normal level of dopamine, you undershoot, so the contrast is even greater. Our Favorite Neurotransmitters `I think I can, I think I can …': 5 brain chemicals and why they're important | Better Nutrition | Find Articles at BNET